Specification
item | value |
CAS No. | 96-50-4 |
MF | C3H4N2S |
EINECS No. | 202-511-6 |
Place of Origin | China |
Type | Syntheses Material Intermediates, One to one service |
Purity | 99.5% |
Application | Chemical/Researching usage |
Appearance | Yellow |
Melting point | 91-93 °C (lit.) |
Boiling point | 117 °C (15.002 mmHg) |
density | 1.241 (estimate) |
vapor pressure | <1 hPa (20 °C) |
refractive index | 1.5300 (estimate) |
Fp | 117°C/15mm |
storage temp. | Store below +30°C. |
solubility | 1 M HCl: soluble50mg/mL, clear (dark yellow-brown) |
pka | 5.36(at 20℃) |
form | Crystalline Powder, Grains, Lumps or Flakes |
color | Brown |
PH | 9.6 (100g/l, H2O, 20℃) |
Water Solubility | 100 g/L (20 ºC) |
Chemical property: white or light yellow crystal. The melting point is 93 ℃, and the boiling point is 140 ℃ (1.47kPa). Soluble in hot water, dilute hydrochloric acid and 20% sulfuric acid, slightly soluble in cold water, ethanol and ether.
Use: Used as intermediate of medicine and dye. For organic synthesis. 2-aminothiazole is mainly used to synthesize nitrosulfathiazole, sulfathiazole, sulfosuccinidium, carbothiazole, phthalylsulfathiazole, Oxyquinolinaphthalysulfathiazole Salazosulfathiazole is used to conduct mild Ulmann coupling reaction with 2-chlorobenzoic acid under ultrasound irradiation
Production method: Thiourea and chloroacetaldehyde (or ethanol and chlorine, or α,β Dichloroethyl ether) is obtained by cyclization. Add hot water, thiourea and α,β- Dichloroethyl ether. Reflux under stirring for 2h. After cooling, sodium hydroxide solution is added into the dropping funnel to make the solution alkaline, and 2-aminothiazole crystal is precipitated. Then add ether to dissolve it. Separate the ether layer, wash it with water, dry it with anhydrous sodium sulfate, and steam out ether to obtain crude product. Use ethanol to recrystallize to obtain yellow crystals. The yield is 80% and the melting point is 90 ℃.
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